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Home  |   Publications  |  Prevalence of genetic variants associated with cardiovascular disease risk and drug response in the Southern Indian population of Kerala

Prevalence of genetic variants associated with cardiovascular disease risk and drug response in the Southern Indian population of Kerala

Lakshmi Mahadevan, Ancy Yesudas, PK Sajesh, S Revu, Prasanna Kumar, Devi Santhosh, Sam Santhosh, JM Sashikumar, VK Gopalakrishnan, Joji Boben, Changanamkandath Rajesh (2014). Indian Journal of Human Genetics, Vol. 20, Issue: 2, 175-184.

We have identified that certain variants associated with cardiovascular disease and related drug response in the five genes, especially those in VKORC1, CYP2C19 and MYBPC3, are highly prevalent in the Kerala population, with almost 2 times higher prevalence of CYP2C19*2 variant compared with other regions in the country. Since the variants chosen in this study have relevance in disease phenotype and/or drug response, and are detected at a higher frequency, this study is likely to encourage clinicians to perform genetic testing before prescribing therapy.

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