Exome Sequencing is a technique to analyse only coding region of the genome. It is a cheaper compared to Whole Genome Sequencing. Exome Sequencing is quite effective in cancer genomics and also to study rare diseases.
RNA Sequencing is a powerful technique that allows researchers to study the complete transcriptome profiling. Transcriptome is complete set of transcripts, including their quantities available in the cell, for specific physiological condition. Complete understanding of transcriptome gives enormous information on functional components of genome, molecular components of cell, tissues and knowledge on disease development.
Different technologies such as Hybridization-based, sequence-based approaches and specialised microarrays have also been used earlier to study transcriptome, but they were found to be not so effective for large volumes of data. Development of RNA-Seq based on the high-throughput DNA sequencing method has solved that problem to a great extent.
Source : Nat Rev Genet. 2009 Jan; 10(1): 57–63.
Gene Panel Sequencing is an approach to focus on specific mutations based on our genes/disease of interest. Gene panels are built with selected group of genes or specific gene regions which are already confirmed to have been associated with certain diseases or phenotypes. One can get their own customized gene panels as per their requirements. Research can be done on multiple samples in parallel, as selective gene sequencing produces small volumes of data when compared to Whole Genome Sequencing.
MedGenome has state-of-the-art Next Generation Sequencing Illumina platforms Miseq, Hiseq 4000 / 2500 and X10 at its facilities in Foster City, California and Bangalore, India.